HPA axis functioning associated with transition to psychosis: combined DEX/CRH test.
Identifieur interne : 003B67 ( Main/Exploration ); précédent : 003B66; suivant : 003B68HPA axis functioning associated with transition to psychosis: combined DEX/CRH test.
Auteurs : K N Thompson [Australie] ; G. Berger ; L J Phillips ; P. Komesaroff ; R. Purcell ; P D McgorrySource :
- Journal of psychiatric research [ 0022-3956 ] ; 2007.
Descripteurs français
- KwdFr :
- Adolescent (MeSH), Adulte (MeSH), Axe hypophyso-surrénalien (physiopathologie), Axe hypothalamohypophysaire (métabolisme), Axe hypothalamohypophysaire (physiopathologie), Corticolibérine (pharmacocinétique), Dexaméthasone (pharmacocinétique), Diagnostic and stastistical manual of mental disorders (USA) (MeSH), Enquêtes et questionnaires (MeSH), Femelle (MeSH), Glucocorticoïdes (pharmacocinétique), Hormone corticotrope (métabolisme), Humains (MeSH), Hydrocortisone (métabolisme), Maladie aigüe (MeSH), Mâle (MeSH), Troubles psychotiques (physiopathologie), Échelle abrégée d'appréciation psychiatrique (MeSH).
- MESH :
- métabolisme : Axe hypothalamohypophysaire, Hormone corticotrope, Hydrocortisone.
- pharmacocinétique : Corticolibérine, Dexaméthasone, Glucocorticoïdes.
- physiopathologie : Axe hypophyso-surrénalien, Axe hypothalamohypophysaire, Troubles psychotiques.
- Adolescent, Adulte, Diagnostic and stastistical manual of mental disorders (USA), Enquêtes et questionnaires, Femelle, Humains, Maladie aigüe, Mâle, Échelle abrégée d'appréciation psychiatrique.
English descriptors
- KwdEn :
- Acute Disease (MeSH), Adolescent (MeSH), Adrenocorticotropic Hormone (metabolism), Adult (MeSH), Brief Psychiatric Rating Scale (MeSH), Corticotropin-Releasing Hormone (pharmacokinetics), Dexamethasone (pharmacokinetics), Diagnostic and Statistical Manual of Mental Disorders (MeSH), Female (MeSH), Glucocorticoids (pharmacokinetics), Humans (MeSH), Hydrocortisone (metabolism), Hypothalamo-Hypophyseal System (metabolism), Hypothalamo-Hypophyseal System (physiopathology), Male (MeSH), Pituitary-Adrenal System (physiopathology), Psychotic Disorders (physiopathology), Surveys and Questionnaires (MeSH).
- MESH :
- chemical , metabolism : Adrenocorticotropic Hormone, Hydrocortisone.
- chemical , pharmacokinetics : Corticotropin-Releasing Hormone, Dexamethasone, Glucocorticoids.
- metabolism : Hypothalamo-Hypophyseal System.
- physiopathology : Hypothalamo-Hypophyseal System, Pituitary-Adrenal System, Psychotic Disorders.
- Acute Disease, Adolescent, Adult, Brief Psychiatric Rating Scale, Diagnostic and Statistical Manual of Mental Disorders, Female, Humans, Male, Surveys and Questionnaires.
Abstract
We investigated functioning of the hypothalamic-pituitary-adrenal (HPA) axis in 12 young people at ultra high risk for developing psychosis, using the combined dexamethasone corticotrophin releasing hormone (DEX/CRH) test. Over a two year period, three of the 12 participants developed an acute psychosis. Descriptive analysis of the data indicated that contrary to expectations, participants who did not make the transition to psychosis had on average higher cortisol levels at the latter stages of the test, as well as a greater severity of depression and anxiety symptoms, than participants who subsequently developed psychosis. These preliminary results suggest that dysregulated HPA-axis functioning in individuals at high risk for psychosis may be associated more with comorbid depression symptoms than factors specifically related to the process of emerging psychosis illness.
DOI: 10.1016/j.jpsychires.2005.11.010
PubMed: 16403528
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Over a two year period, three of the 12 participants developed an acute psychosis. Descriptive analysis of the data indicated that contrary to expectations, participants who did not make the transition to psychosis had on average higher cortisol levels at the latter stages of the test, as well as a greater severity of depression and anxiety symptoms, than participants who subsequently developed psychosis. 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Over a two year period, three of the 12 participants developed an acute psychosis. Descriptive analysis of the data indicated that contrary to expectations, participants who did not make the transition to psychosis had on average higher cortisol levels at the latter stages of the test, as well as a greater severity of depression and anxiety symptoms, than participants who subsequently developed psychosis. These preliminary results suggest that dysregulated HPA-axis functioning in individuals at high risk for psychosis may be associated more with comorbid depression symptoms than factors specifically related to the process of emerging psychosis illness.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Thompson</LastName><ForeName>K N</ForeName><Initials>KN</Initials><AffiliationInfo><Affiliation>ORYGEN Research Centre, Department of Psychiatry, University of Melbourne, Poplar Road, Locked Bag 10, Parkville, Victoria 3052, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Berger</LastName><ForeName>G</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Phillips</LastName><ForeName>L J</ForeName><Initials>LJ</Initials></Author><Author ValidYN="Y"><LastName>Komesaroff</LastName><ForeName>P</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Purcell</LastName><ForeName>R</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>McGorry</LastName><ForeName>P D</ForeName><Initials>PD</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2006</Year><Month>01</Month><Day>03</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Psychiatr Res</MedlineTA><NlmUniqueID>0376331</NlmUniqueID><ISSNLinking>0022-3956</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005938">Glucocorticoids</NameOfSubstance></Chemical><Chemical><RegistryNumber>7S5I7G3JQL</RegistryNumber><NameOfSubstance UI="D003907">Dexamethasone</NameOfSubstance></Chemical><Chemical><RegistryNumber>9002-60-2</RegistryNumber><NameOfSubstance UI="D000324">Adrenocorticotropic 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IdType="doi">10.1016/j.jpsychires.2005.11.010</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li></country><region><li>Victoria (État)</li></region><settlement><li>Melbourne</li></settlement><orgName><li>Université de Melbourne</li></orgName></list><tree><noCountry><name sortKey="Berger, G" sort="Berger, G" uniqKey="Berger G" first="G" last="Berger">G. Berger</name><name sortKey="Komesaroff, P" sort="Komesaroff, P" uniqKey="Komesaroff P" first="P" last="Komesaroff">P. Komesaroff</name><name sortKey="Mcgorry, P D" sort="Mcgorry, P D" uniqKey="Mcgorry P" first="P D" last="Mcgorry">P D Mcgorry</name><name sortKey="Phillips, L J" sort="Phillips, L J" uniqKey="Phillips L" first="L J" last="Phillips">L J Phillips</name><name sortKey="Purcell, R" sort="Purcell, R" uniqKey="Purcell R" first="R" last="Purcell">R. Purcell</name></noCountry><country name="Australie"><region name="Victoria (État)"><name sortKey="Thompson, K N" sort="Thompson, K N" uniqKey="Thompson K" first="K N" last="Thompson">K N Thompson</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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